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Comment Response

Response to Comment on “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”

AbstractIn evaluating any randomized clinical trial, it is important to determine whether baseline differences between groups could have affected the primary outcome. In our study, muscle insulin sensitivity, which was identical in both groups at baseline, improved after nicotinamide mononucleotide (NMN), not placebo, therapy. Differences in baseline intrahepatic triglyceride content between groups do not negate…

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Comment Response

Response to Comment on “Individual heterozygosity predicts translocation success in threatened desert tortoises”

AbstractHansson et al. argue that our main finding could provide an overly simplistic metric for maximizing genetic rescue. They agree that translocating the most genetically diverse individuals led to a large increase in translocated tortoise survival, but recommend instead moving individuals that have low genetic load and the greatest representation of metapopulation diversity. Their recommendation…

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Comment Individual

Comment on “Individual heterozygosity predicts translocation success in threatened desert tortoises”

AbstractScott et al. (Reports, 27 November 2020, p. 1086) suggest, on the basis of conclusions obtained from a desert tortoise reintroduction program, that higher genomic heterozygosity should be used to identify individuals for successful translocation. I contend that this recommendation is questionable given these relocated tortoises’ unknown origin, their high mortality, insufficient data on resident…

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Comment previous

I concur with @tres in the prior remark. Please make a contrast, ideally asking…

Looking at the screen, the X1 Titanium has the advantage of the 3:2 aspect ratio, which offers more vertical space. However, the new 16:10 panel of the X1 Yoga G6 is a big improvement and then there is the advantage of the matte capacitive touchscreen. The subjective picture impression is still very good, and even…

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circadian Comment

Comment on “Circadian rhythms in the absence of the clock gene Bmal1”

AbstractRay et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1–/– liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.Note: Although this Comment originally addressed the version published on 14 February…